Regarding genetic thrombophilia, five patients had more than one thrombophilia: one antithrombin deficiency and factor II 20210A mutation, one protein S deficiency and Factor V Leiden mutation, two protein S deficiencies and Factor II 20210A mutation, and one association of homozygous factor V Leiden mutation and heterozygous factor II 20210A mutation. This evidence concerns the gene PROS1 and hyperinsulinemic hypoglycemia, familial, 4.