Regarding genetic thrombophilia, five patients had more than one thrombophilia: one antithrombin deficiency and factor II 20210A mutation, one protein S deficiency and Factor V Leiden mutation, two protein S deficiencies and Factor II 20210A mutation, and one association of homozygous factor V Leiden mutation and heterozygous factor II 20210A mutation. The gene discussed is PROS1; the disease is thrombophilia.