AKR1B1 and hyperinsulinemic hypoglycemia, familial, 4: Cortese et al. found a complete loss of SORD protein and increased intracellular sorbitol in patient-derived fibroblasts, and the aldose reductase inhibitor epalrestat or ranirestat rescued the lack of SORD orthologs that caused synaptic degeneration and motor deficiency in Drosophila (4).