Cortese et al. found a complete loss of SORD protein and increased intracellular sorbitol in patient-derived fibroblasts, and the aldose reductase inhibitor epalrestat or ranirestat rescued the lack of SORD orthologs that caused synaptic degeneration and motor deficiency in Drosophila (4). The gene discussed is SORD; the disease is hyperinsulinemic hypoglycemia, familial, 4.