AhR plays an important role in clonogenic survival (Opitz et al., 2011; Sadik et al., 2020), motility (Opitz et al., 2011; Sadik et al., 2020), promoting pro-oncogenic cytokine production such as TGF-β (Gramatzki et al., 2009), immunosuppression by its effects on T-cells (Ehrlich et al., 2018; Prasad Singh et al., 2020), DCs (Goudot et al., 2017), macrophages (Goudot et al., 2017), natural killer cells (Shin et al., 2013), B-cells (Piper et al., 2019), or glioblastoma-specific tumor-associated macrophages (Takenaka et al., 2019). The gene discussed is AHR; the disease is glioblastoma.