HMOX1 and Insulin resistance: Tan IIA treatment increased immune cell precipitation in renal cells and improved the lipid and glucose metabolism, insulin resistance, and body weight in type 2 DM Rats (Yuan et al., 2018), attenuates renal injury by reducing excessive oxidative stress and inflammation, and the mechanisms include activating Nrf2, and upregulating heme oxygenase-1 (HO-1) expression (Liang et al., 2018), and enhancement of glutathione mediated detoxification pathways (Li W. et al., 2019).