EGFR and non-small cell lung carcinoma: Furthermore, studies have confirmed that Tan IIA can be used as an EGFR inhibitor to reduce the level of myeloid cell leukemia 1 (Mcl-1) protein by ubiquitin, and target EGFR-Akt-Mcl1 axis to inhibit non-small cell lung cancer (NSCLC) (Gao et al., 2020).