The HGK (MAP4K4 or mitogen activated protein kinase kinase)-SAPK/JNK-Jun signal axis can be recruited to the SESN2 promoter to activate SESN2/AMPK-α and induce Tan IIA -mediated autophagy and osteosarcoma growth inhibition (Yen et al., 2018). Here, MAP4K4 is linked to osteosarcoma.