Both pathways represent important signal transduction mechanisms that promote the proliferation and survival of cancers driven by growth factor receptors such as factor 1 receptor (IGF1R), vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) or human epidermal growth factor receptor 2 (Her2) (Su, 2018a). This evidence concerns the gene ERBB2 and cancer.