Innate immune pathways are also increasingly considered to play an important role in the pathogenesis of hyperuricemia (Kielstein et al., 2020), and particularly lead to activation of the NLRP3 inflammasome which contributes to the release of IL-1β and other pro-inflammatory cytokines (So and Martinon, 2017). This evidence concerns the gene NLRP3 and hyperuricemia.