The mutations of the hepatobiliary transporter genes, especially bile salt export pump (BSEP), multidrug resistance protein 3 (MDR3) and multidrug-resistance-associated protein 2 (MRP2), can increase the susceptibility to EIC (Sookoian et al., 2008; Anzivino et al., 2013). The gene discussed is ABCB4; the disease is Epidermal Inclusion Cyst.