In addition, studies have found that cholestasis induced by E217G is related to internalization of the canalicular transporters such as BSEP and MRP2 (Figure 2), which is relevant to bile secretion (Crocenzi et al., 2003; Majer et al., 2007; Miszczuk et al., 2018). This evidence concerns the gene ABCC2 and cholestasis.