We found that the homologous genes of makers in our C3:Ex.Neuron, TSHZ2, and MEF2C, were also highly expressed in the human Ex.Neurons from both Healthy and AD-early groups (Supplementary Figure 6A), suggesting the similarity of the mouse C3:Ex.Neuron and human Ex.Neuron. The gene discussed is TSHZ2; the disease is Alzheimer disease.