Notably, human mutations in CYP450 hydroxylase enzymes, particularly CYP4A11 and CYP4F2, are linked with increased prevalence of ischemic stroke and hypertension (Fu et al., 2008; Deng et al., 2010; Fava et al., 2012; Roman and Fan, 2018), especially in males, while certain single nucleotide polymorphisms in CYP4F2 are associated with decreased 20-HETE production (Stec et al., 2007). This evidence concerns the gene CYP4F2 and hypertensive disorder.