In particular, an HF diet profoundly reorganizes specific metabolic pathways, with a widespread remodeling of the liver clock, ablates some transcript and metabolite oscillations, generates new oscillating transcripts and, in contrast to Barnea (Barnea et al., 2009, 2010), observed that it induces a phase advance for many metabolites and oscillating transcripts. The gene discussed is CLOCK; the disease is hydrops fetalis.