CLOCK and hydrops fetalis: Kohsaka et al. (2007) fed mice with a regular chow or an HF diet for 6 weeks. After 7 days, before a significant weight gain, mice fed with HF diet reduced their overall physical activity and increased the food intake during the resting period. Core clock gene expression was not affected in the hypothalamus, but the amplitude of Clock and Bmal1 expression was attenuated in fat and liver.