When we analyzed the patients with high-grade DLBCLs-NOS (n = 5), those with double-hit/triple-hit (n = 4) DLBCLs, and those with DLBCL-NOS (n = 20), c-MYC and TCF3 were more present in the high-grade DLBCLs-NOS than in the DLBCLs-NOS (44% vs. 15%, p = 0.1; and 22% vs. 0%, p = 0.089, respectively). This evidence concerns the gene TCF3 and diffuse large B-cell lymphoma.