In contrast, mutations in genes encoding proteins implicated in B-cell receptor signaling and the nuclear factor kappa-light-chain-enhancer of activated B cells pathway (such as CD79b and MYD88) and genes involved in the regulation of the cell cycle (such as CDKN2A) contribute to the molecular pathogenesis of ABC DLBCL5,19,20. This evidence concerns the gene CD79B and aneurysmal bone cyst.