Moreover, the CSF NSE levels were significantly higher in patients with ALS who had an ALSFRS-R score of > 36 (22.4 ± 5.3 ng/mL) than in those with an ALSFRS-R score of ≤ 36 (19.2 ± 4.3 ng/mL, P = 0.037). The gene discussed is ENO2; the disease is amyotrophic lateral sclerosis.