The ALS group (mean ± standard deviation: 21.0 ± 5.1 ng/mL) had significantly higher CSF NSE levels than the CSM (13.7 ± 4.3 ng/mL, P < 0.001) and control (13.6 ± 4.0 ng/mL, P < 0.001) groups (Fig. 1). This evidence concerns the gene ENO2 and amyotrophic lateral sclerosis.