This shape-based nature enabled us to discover multiple unique protein–phenotype links, including cathepsin H and type 1 diabetes (rs2289702 within CTSH), TREM-like transcript 2 protein and monocyte count (rs62396355 within TREML2) or plexin-B2 and systolic blood pressure (rs28379706 within PLXNB2) (Supplementary Data 11). This evidence concerns the gene CTSH and type 1 diabetes mellitus.