GDF15 and hyperemesis gravidarum: The G-allele mediating the amino acid substitution was associated with higher GDF-15 recognition by the SomaScan assay (beta = 0.39, p < 4.7 × 10−174), but with 32% reduced risk for hyperemesis gravidarum (odds ratio: 0.68, 95% CI: 0.62–0.75, p < 3.4 × 10−14) as well as a higher risk for childhood obesity (beta = 0.01, p value < 6.7 × 10−13) and reported coffee intake (beta = 0.01, p value = 5.6 × 10−8) clearly opposing the well-documented effects of high circulating GDF-1535.