These included established cardiovascular risk loci such as FGF5 (e.g., hypertension39, coronary heart disease40 or atrial fibrillation41) and UMOD (e.g., hypertension and estimated glomerular filtration rate42) for which we estimate that genetically higher protein levels are causally associated with higher disease risk, for instance, a 1 s.d. This evidence concerns the gene FGF5 and hypertensive disorder.