In particular, it will be interesting to determine whether activation of MRTF/SRF-dependent transcription imparts pro-invasive/metastatic characteristics to EphA2-driven cell : cell repulsive events and whether that signalling is dependent on the balance between the levels of EphA2 expressed in the cancer cells and the abundance of ephrin ligands present in the tumour microenvironment. Here, SRF is linked to cancer.