KRAS and pancreatic ductal adenocarcinoma: Indeed, we have previously reported that an autochthonous model of pancreatic ductal adenocarcinoma (PDAC)—the ‘KPC’ model, which is driven by expression of mutants of Kras (K) and Trp53 (P) under control of a pancreatic-specific Cre (C) recombinase—display reduced metastasis when conducted in EphA2-knockout mice14.