In addition to the MC38 tumor model, we found that LSD1 depletion also led to the expansion of TCF1+PD-1int CD8+ TILs in pool size in the TRAMP-C2 tumor model, which was associated with the increased CD8+ T cell infiltration and the decreased PD-1 expression level by CD8+ TILs (Supplementary Fig. 7a–g). This evidence concerns the gene TCF7 and neoplasm.