To further evaluate the expansion ability of tumor-resident CD8+ T cells with or without LSD1, we isolated CD8+ TILs from MC38 tumor-bearing Cd4-Cre+Lsd1f/f (CD45.2+) and congenic wildtype (CD45.1+) mice and co-transferred those cells into TCRα KO recipient mice receiving MC38 tumors, followed by TIL analysis 14 days later (Fig. 3e). The gene discussed is CD8A; the disease is neoplasm.