To investigate the role of LSD1 in T cell immunity in the cancer context, we generated T cell-specific Lsd1 knockout (Cd4-Cre+Lsd1f/f) mice, which showed largely unaltered αβ T cell development (Supplementary Fig. 1a–c) and displayed an increased central memory phenotype of T cells in peripheral lymphoid organs (Supplementary Fig. 1d–l). This evidence concerns the gene CD4 and cancer.