To examine the local expansion of CD8+ T cells in the TME and its regulation by LSD1, we implanted MC38 tumors in Cd4-Cre+Lsd1f/f mice and littermate controls for 12 days to allow initial T cell infiltration in comparable numbers and then treated those mice with FTY720, a S1P receptor agonist that can block additional T cell recruitment from lymph nodes to tumor sites (Fig. 3a). This evidence concerns the gene CD4 and neoplasm.