CD4 and neoplasm: To elucidate the immunologic basis underlying this phenotype, we analyzed tumor-infiltrating leukocytes (TILs) from MC38 tumor-bearing Cd4-Cre+Lsd1f/f mice and littermate controls at two time points (day 12 and day 18), corresponding to the two stages, which allowed for intra-group longitudinal comparisons as well as inter-group comparisons.