Using MC38-OVA and tetramer staining, we further showed that tumor antigen-specific CD8+ TILs consistently displayed an elevated TCF1+PD-1int subset in response to LSD1 loss (Fig. 4f), while in TdLNs, TCF1+PD-1int subset remained numerically unaltered (Supplementary Fig. 5a–c). The gene discussed is CD8A; the disease is neoplasm.