TCF7 and neoplasm: In line with those reports, we showed that isolated CD8+ TILs with the PD-1int phenotype, when adoptively transferred into MC38 tumor-bearing mice, retained a limited but detectable number of TCF1+PD-1int cells in the TME, while converting into numerically more TCF1-PD-1hi cells than did transferred PD-1hi cells (Supplementary Fig. 4a–g).