Interestingly, GSEA of genes positively or negatively correlating with ATR expression in human NB tumours (Kocak-649- GSE45547), using the R2: Genomics Analysis and Visualization Platform (http://r2.amc.nl), revealed a Hallmark gene set signature (Fig. 7f) that is nearly identical to the ATR inhibition response observed in either our NB cell lines (Fig. 3b–d) or mouse model RNA-Seq datasets (Fig. 7a–c). The gene discussed is ATR; the disease is neuroblastoma.