We find that BAY 1895344 effectively inhibits ATR but not ATM34 in NB cells, and observe upregulation of ATM phosphorylation on S2996, which is a previously reported ATM autophosphorylation site45, together with a number of downstream substrates in our phosphoproteomics analysis suggesting that addition of BAY 1895344, while inhibiting ATR, results in an upregulation of ATM presumably as a compensatory measure (Fig. 4). The gene discussed is ATM; the disease is neuroblastoma.