SHANK2 and neoplasm: In addition to loss of tumour suppressors such as DLG2 or SHANK2, this region contains many genes involved in the DDR, such as ATM, CHEK1, H2AFX and MRE11, as noted previously by others37, raising the possibility that, e.g. 11q loss in NB may make NB more dependent on ATR in the response to oncogene-induced stress.