PRRs and these adaptor molecules are also involved in ARDS caused by viral infection, and it has been reported that TICAM-1 had a protective role in ARDS caused by SARS-CoV, showing increased mortality, weight loss, and reduced lung function in Ticam-1 KO mice (Totura et al, 2015). Here, TICAM1 is linked to acute respiratory distress syndrome.