GPT and acute kidney injury: In contrast to the development of severe DAH, pristane treatment of Tank−/− mice did not lead to the cause of hepatic, pancreatic, or acute renal failure as examined by the serum levels of transaminases (AST and ALT), urea nitrogen (BUN), creatinine (Cre), and albumin (Alb), or histological changes in glomeruli and heart (Fig S1C–F).