Furthermore, 6-mo-old Tank−/−Ifnar2−/− mice developed glomerulonephritis with mesangial cell proliferation and expansion of the mesangial matrix (Fig S1G), whereas the absence of IL-6 completely prevented the mice from glomerulonephritis as previously reported (Kawagoe et al, 2009). The gene discussed is IL6; the disease is glomerulonephritis.