We found that TGFβ signaling as well as activation of YAP/TAZ induced by knockdown of LATS1/2 led to strong induction of a proliferative-to-invasive phenotype switch, whereas canonical Wnt/β-catenin signaling rather promoted the proliferative phenotype of patient-derived melanoma cells, yet was required but not sufficient for the phenotype switch downstream of TGFβ and YAP/TAZ signaling. This evidence concerns the gene LATS1 and melanoma.