Whereas TGFβ/SMAD2/3 and Hippo/YAP/TAZ have also been shown to be strong inducers of a proliferative-to-invasive phenotype switch and to promote melanoma progression and metastasis (Perrot et al, 2013; Nallet-Staub et al, 2014; Schlegel et al, 2015; Verfaillie et al, 2015), the role of Wnt/β-catenin signaling in melanoma progression is obscured by conflicting experimental results (Widlund et al, 2002; Chien et al, 2009; Arozarena et al, 2011; Damsky et al, 2011; Eichhoff et al, 2011; Kovacs et al, 2016). The gene discussed is SMAD2; the disease is melanoma.