SOX10 is preferentially expressed in the neural crest, transitory and melanocytic phenotypes (Fig. 1E) and plays a key role in melanocyte and melanoma biology (Seberg et al. 2017a), while the TEAD transcription factor lies downstream from the Hippo signaling pathway implicated in response to mechanical stress and control of organ size and apoptosis (Ma et al. 2019). The gene discussed is SOX10; the disease is melanoma.