TBX2 and breast cancer: One candidate is TBX2, a key developmental transcription repressor (Naiche et al. 2005; Abrahams et al. 2010; Ghosh et al. 2017) that was identified in a senescence bypass screen in breast cancer, where it was shown to suppress p16INK4A (CDKN2A) expression (Jacobs et al. 2000).