Consistent with this, the mass spectrometry analysis (Fig. 6B,C) revealed a range of potentially cooperating transcription factors, including NKX2.5, a homeodomain transcription factor already known to facilitate cooperative DNA binding by TBX2 (Habets et al. 2002); TCF7L2 (TCF4), which recruits β-catenin to target genes and is preferentially expressed in invasive phenotype melanoma cells (Eichhoff et al. 2011); and TFAP2, which plays a key role in controlling melanocyte differentiation (Seberg et al. 2017b). The gene discussed is TBX2; the disease is melanoma.