MITF and melanoma: This sequence represents a consensus for recognition by the basic helix–loop–helix leucine zipper (bHLH-LZ) microphthalmia-associated transcription factor MITF (Aksan and Goding 1998), which controls many aspects of melanocyte development and melanoma biology (Goding and Arnheiter 2019), as well as by the bHLH-LZ transcription factors USF1 and USF2, which are implicated in control of expression of a wide range of E-box-containing genes (Corre and Galibert 2005).