Previous work identified TBX2 as a target for retinoic acid receptor (Boskovic and Niles 2004), a PML–E2F4 complex (Martin et al. 2012), Sonic Hedgehog (Lüdtke et al. 2016), and WNT (Aydoğdu et al. 2018) as well as PAX3, a lineage-restricted transcription factor that plays a key role in melanocyte development and in melanoma (Liu et al. 2013). Here, E2F4 is linked to melanoma.