In part, this may be because TBX2 can be regulated by PAX3 (Liu et al. 2013), a key melanocyte transcription factor that can promote a melanogenic gene expression program but that also prevents differentiation (Lang et al. 2005), and potentially by the microphthalmia-associated transcription factor MITF (Carreira et al. 2000; Béjar et al. 2003), a key regulator of melanoma biology (Goding and Arnheiter 2019). Here, TBX2 is linked to melanoma.