Significantly, we also reveal that TBX2 directly represses PTEN in melanoma, a result consistent with observations in rhabdomysosarcoma (Zhu et al. 2016) and nasopharyngeal carcinoma (Lv et al. 2017), where TBX2-mediated repression of PTEN mRNA expression has been observed. This evidence concerns the gene PTEN and nasopharyngeal carcinoma.