Specifically, the upregulation of TLRs, including Tlr1, Tlr2, and Tlr4, scavenger receptors, including Scarb2, Cd68, Msr1, and Cxcl16, and other lipid mediators, including Npc1, Npc2, Lamp1, Ffar1, Pparg, Apoe, Trem2, and Abca1, indicates a pronounced disruption in lipid homeostasis at 7 weeks after stroke. The gene discussed is TREM2; the disease is Stroke.