CREB1 and Alzheimer disease: Yeom et al. [49] hypothesized that the increased striatal BDNF concentration,along with phospho-DARPP32 and phospho-CREB, in a mouse AD model, was associated with thedepressive-like behavior and increased activity of the dopaminergic reward circuitry, whichis central in mediating anxiety, depression, and stress (Table 1).