Metabolite 16α-hydroxyestrone (16αOHE), one of the estrogens, can promote the development of HPAH through upregulation of miR-29; the improvement of HPAH in Bmpr2 mice after treated with anti-miR-29, revealing the potential of this miRNA as a therapeutic target of HPAH [39]. The gene discussed is BMPR2; the disease is heritable pulmonary arterial hypertension.