For example, ciglitazone, a thiazolidonedione with potential interest in ovarian hyperstimulation syndrome or as an anti-hyperglycemic agent is a selective agonist to the nuclear receptor PPARy (Peroxisome proliferator-activated receptor gamma) and shows morphological perturbations for different features i.e., “Cytoplasm_Correlation_Manders_DNA_ER”, “Cytoplasm_Correlation_Manders_RNA_ER”' or “Cells_Correlation_Manders_Mito_ER”. Here, PPARG is linked to ovarian hyperstimulation syndrome.