However, evidence that RASL12 functions as a small GTP-binding protein is lacking; In fact, studies have reported that RASL12 could be homologous to the RAS-like GTPases RERG, RASL11A, RASL11B, RASL10A and RASL10B, which play tumor-suppressive roles in human cancers [43–45]. This evidence concerns the gene RASL10B and cancer.