Recent reports highlighted that GPRC5A and IMUP were involved in several human cancers via participated in various tumor-associated signaling pathways, for instance the nuclear factor (NF)-κB [42–44], signal transducer and activator of transcription (STAT) 3 [45, 46], and focal adhesion kinase (FAK)/Src signaling [47–51], however, they are still on the way to be validated in PAAD. This evidence concerns the gene GPRC5A and pancreatic adenocarcinoma.