The IHC experiment conducted on PAAD tissue microarray verified that the positive ratio of both GPRC5A and IMUP were much higher in cancer (74.6 and 46.8% respectively) than matched normal pancreatic samples (both less than 5%), supporting the aberrant gain of expression of GPRC5A and IMUP in PAAD (Fig. 5K–O). This evidence concerns the gene GPRC5A and cancer.