Meanwhile, although several mutation sites in GPRC5A gene were reported in human tumors, they were mainly discovered in other tumors, for instance uterine endometrioid carcinoma, lung squamous cell carcinoma and bladder urothelial carcinoma, none mutation has been tested for GPRC5A gene in PAAD. This evidence concerns the gene GPRC5A and endometrial endometrioid adenocarcinoma.