Actually, to identify the potential “unique key genes” during PAAD development, we then combine used KM survival, UALCAN survival and multivariate Cox Regression analysis to successively explore the association between 55 over eightfold genes and PAAD patient survival, and the results highlighted two genes: GPRC5A and IMUP, which were supported by all three analysis to be associated with both patients overall and recurrence free survival and worked as independent prognostic indicators in PAAD development. This evidence concerns the gene GPRC5A and pancreatic adenocarcinoma.