The recently published SURPASS-2 has been conducted in order to compare the efficacy and safety of the three doses of tirzepatide with the GLP-1 agonist semaglutide at an injectable dose of 1 mg in patients with T2DM inadequately controlled with metformin monotherapy; it has been performed in an open-label, 40-week, phase 3 trial [25]. Here, GCG is linked to type 2 diabetes mellitus.