Also, Ene-Obong et al. [53] reported that in KPC (Pdx-1-Cre; LSL-KrasG12D/ + ; LSL-Trp53R172H/ +) mice, PSCs sequester antitumor CD8+ T cells around nonadjacent regions in the stroma, resulting in the dysfunction of CD8+ cells to infiltrate into the pancreatic tumor epithelial cells. This evidence concerns the gene CD8A and pancreatic neoplasm.