At 12–24 h, the SNR of tumors treated with MPDA@SPIO/SA-PEI/AFP-Fth nano preparations was still weakening, and the tumor slices were in 24 h showed SNR=25.2, when ferritin expression reached the level required for measurable T2W1 effect, Fth reporter gene with AFP promoter could be worked. This evidence concerns the gene AFP and neoplasm.