It was disclosed that the upregulation of miR-140-3p decreases the expression of VEGF in CRC cells, which is associated with the aggressiveness of CRC, as well as the discovery, which proves that the silenced miR-140-3p restrains the angiogenesis in endothelial cells (ECs), while the overexpressed miR-140-3p did conversely [34]. Here, VEGFA is linked to colorectal carcinoma.