E-cadherin, a glycoprotein with transmembrane property, has been identified as pivotal in cell–cell adhesion and has been recognized to act as an inhibitor in malignancies, while N-cadherin, on the contrary, endows malignant cells with promotive effect on metastasis, and the acquisition of N-cadherin in tumor cells is regarded as a vital step in epithelial cancer metastasis [29,30]. Here, CDH2 is linked to neoplasm.