CTLA4 and neoplasm: Strikingly, single-dose AIPV administered to animals bearing large ~40–50 mm2 tumors followed by PD-1 and CTLA-4 blockade (hereafter, ICB) led to tumor regressions comparable with the “full” AIPV regimen, with complete responses in 80% of animals (Figures 1D and 1E).