On the other hand, gene signatures that have been shown to be associated with M2-like macrophages (Orecchioni et al., 2019), such as Il10, Cd36 (Vats et al., 2006), B4galnt1, Dgkz, Gab1 (Guo et al., 2017), and Jun, were downregulated in the AIP treatment group, indicating a pro-inflammatory signature in these cells. This evidence concerns the gene IL10 and autoimmune pancreatitis.