In this study, a series of bioinformatic analysis identified 10 hub genes (MX1, MX2, RSAD2, STAT1, IFI35, ISG15, OAS3, OAS1, IFI6, and IFI44L) between skeletal muscle biopsy of DM and HC samples based on the gene expression profiles obtained from GSE48280 and GSE5370 datasets. The gene discussed is ISG15; the disease is dermatomyositis.