Since some recent evidence suggested that the presence of APOE ε4 influence the behavioural effects of ACE I/D polymorphism in AD, and the protective effects of ACE inhibitors or angiotensin receptor blockers on cognitive decline correlated with APOE ε4 carrier status, we also performed subgroup analyses according to APOE ε4 carrier status if sufficient data could be obtained [12, 13]. This evidence concerns the gene ACE and Alzheimer disease.