Besides rs1799752 I/D polymorphism, several other polymorphisms of the ACE gene were also investigated in AD cohorts of different ethnics, such as rs1800764 T/C, rs4343 A/G, rs4291 A/T polymorphisms, et al. rs1800764 and rs4291 located in the regulatory region of ACE gene, while rs4343 in the exotic region. This evidence concerns the gene ACE and Alzheimer disease.