APOE and Alzheimer disease: However, after exclusion of HWE-deviated samples [27, 51], in the I homozygotes and the D homozygotes, the presence of APOE ε4 increased the risk of AD 2.84-fold (95% CI = 1.825–4.418, p < 0.001) and 7.06-fold (95% CI = 3.963–12.571, p < 0.001), respectively.