The important roles of folate metabolism and nucleic acid synthesis in cryptosporidiosis, mean that currently, inosine monophosphate dehydrogenase (IMPDH) and dihydrofolate reductase-thymidylate synthase (DHFR-TS) are common targets for the treatment of cryptosporidiosis [71,72]. This evidence concerns the gene DHFR and cryptosporidiosis.