The important roles of folate metabolism and nucleic acid synthesis in cryptosporidiosis, mean that currently, inosine monophosphate dehydrogenase (IMPDH) and dihydrofolate reductase-thymidylate synthase (DHFR-TS) are common targets for the treatment of cryptosporidiosis [71,72]. The gene discussed is TYMS; the disease is cryptosporidiosis.