IL10 and Crohn disease: B. uniformis has been found to be reduced in patients with Crohn’s disease, suggesting an inverse relationship with inflammation.40 Furthermore, we have previously found that it has the genes to produce a zwitterionic capsular polysaccharide predicted to have similar anti-inflammatory properties to Polysaccharide A (PSA) of Bacteroides fragilis41 and induced higher levels of IL-10 and T regulatory cells in in vitro stimulations with PBMC compared to intestinal Bacteroides without this factor.41