Both male and, less frequently, female individuals with 55–200 CGG repeat expansions of the FMR1 gene may develop the fragile X-associated tremor ataxia syndrome (FXTAS), which clinically manifests with progressive cerebellar ataxia, prominent tremor, as well as cognitive impairment, neuropathy, l-Dopa-unresponsive parkinsonism and autonomic failure [74, 79–81]. Here, FMR1 is linked to fragile X-associated tremor/ataxia syndrome.