CRP and influenza: If antibiotics had been given only to those with hypoxia or CRP of >40 mg/L, a cutoff that is more conservative than what was used in other recent studies in SSA demonstrating the safety and efficacy of CRP-based algorithms (15, 16), treatment could have been avoided in 83% (33/40) of influenza-positive and 85% (157/185) of influenza-negative children (Fig. 3).