While all clinically available PPIs were found to have the anti‐inflammatory activity, we particularly confirmed that OM was effective in inhibiting the activation of NF‐κB/AP‐1 and IRF in TLR4 signaling cascades and reducing pro‐inflammatory cytokine production, including IL‐6, TNF‐α, and MCP‐1, in THP‐1 cell‐derived macrophages and human PBMC. This evidence concerns the gene IL6 and ocular melanoma.