GSDMD and neoplasm: Interestingly, we found that NLRP3 mutation tumours showed high expression of CASP6, GSDME, GSDMD, GPX4 and CASP3, and PLCG1 mutation tumours showed a high expression of PJVK, AIM2 and GSDMB and these genes were also regulated by other gene mutations, while CASP1 mutation tumours showed a low expression of PLCG1, NOD1, SCAF11, TIRAP and high expression IL6.