Among these cases, 83 patients were excluded because of the presence of diffuse liver metastases, signs of mild liver damage (T‐Bil > 2.0 mg/dL or ALT > 100 IU/L) including liver cirrhosis, signs of portal hypertension (EGV and/or ascites), or portal vein occlusion before initial chemotherapy. This evidence concerns the gene GPT and liver disorder.