Subsequently, PEDF-specific siRNA was constructed and transfected into OM-MSCs to inhibit >the production of PEDF in OM-MSCs, and the results obtained by PCR, western blotting, and ELISA showed that PEDF siRNA contributed to a notable decrease in the PEDF mRNA and protein levels compared with control siRNA (Supplementary Figure S2A-D). The gene discussed is SERPINF1; the disease is ocular melanoma.