TP53 and breast cancer: We noticed that all the mesenchymal like mammary tumors in our cohort were generated from the MMTV-Cre; Brca1fl/fl;Trp53+/+ mice (Figure 2A), which is contradictory to previous reported role of TRP53 in EMT, where loss of TRP53 could activate EMT through regulation of microRNAs-ZEB1/2, and MEK-ERK signaling, as well as other mechanisms 65-67.