The biological relevance of GzmA in sepsis has been demonstrated in different models of bacterial sepsis, including LPS-induced shock 6, 13, sepsis induced by the mouse bacterial pathogen Brucella microti14, polymicrobial sepsis induced by caecal ligation and puncture 15 and pneumonia induced by Streptococcus pneumoniae16. The gene discussed is GZMA; the disease is bacterial infectious disease with sepsis.