TREM2 and early-onset autosomal dominant Alzheimer disease: Targeting TREM2-APOE signaling eliminated pro-inflammatory macrophages (Ly6C+) in Alzheimer's disease mice, restored the homeostatic signature of microglia, reduced inflammation, ameliorated Aβ deposition and Tau pathology, and prevented neuronal death in an acute model of neurodegeneration 36,52.