Women with PCOS are prone to develop ovarian hyperstimulation syndrome (OHSS) during IVF/ICSI treatment2,3, which can be prevented by a gonadotropin releasing hormone agonist (GnRHa) to trigger final oocyte maturation in a GnRH antagonist (GnRHant) protocol4. Here, GNRH1 is linked to polycystic ovary syndrome.