ACE2 and infection: Aoyagi et al. described a COVID-19 patient who developed dysphagia and observed dysregulated pharyngolaryngeal sensations, mesopharyngeal contractile dysfunction, and silent aspiration through the video endoscopy, high-resolution manometry, and videofluorography implying possible infections of the trigeminal or nasopharyngeal nerves.172 In addition, studies should evaluate the expressions of ACE2, TMPRRSS2, NRP1, and other related proteins to confirm whether these mechanisms can cause CNS infections in COVID-19 patients.