ACE2 was also found to be expressed in postmortem frontal cortex vessels with different calibres and significantly elevated in the brain vasculature of dementia and hypertension patients.136 SARS-CoV-2 was found to invade neurons and then cause their necrosis in the study of human ACE2 transgenic mice as well as brain organoids;137,138 however, the amounts of affected cells were limited due to low TMPRSS2 and ACE2 levels. This evidence concerns the gene ACE2 and hypertensive disorder.