Considering the preferential expression of CAPN14 in esophageal mucosa (Fig. 5c) and its strong association with EoE28, these results provide a potential mechanistic framework to understand the functional significance of the DSP and PPL mutants, as well as a potential mechanism that may link the observed esophagus-specific phenotype (compared to skin or heart disease phenotypes). This evidence concerns the gene DSP and heart disorder.