In this regard, it is also notable that patients with familial EoE harboring DSP or PPL variants expressed higher TSLP mRNA levels than did patients with non-familial EoE (2.1 fold, P = 0.001) (Fig. 2b); the difference in TSLP expression was independent of peak eosinophil levels in the esophagus. This evidence concerns the gene DSP and eosinophilic esophagitis.