DSP and eosinophilic esophagitis: In the case of the discovery family, the second hit is the co-occurrence of damaging variants in both DSP and PPL, whereas, in the replication families, the co-occurrence of the DSP or PPL variants with additional rare variants in other genes in the desmosome were enriched (P = 0.0052, Fisher’s exact test) (Table 2 and S7), providing evidence that rare genetic variants in the desmosomal genes associate with EoE.