Notably, similar to mutated variants in this study, partial gene silencing and some of the known DSP mutations [p.R451G from arrhythmogenic cardiomyopathy and p.H586P from severe dermatitis, multiple allergies, and metabolic wasting (SAM) syndrome]20,21 also showed increased cell motility (Supplementary Fig. 10b and d). Here, DSP is linked to dermatitis.