AKT1 and cancer: Phosphoinositide 3-kinase (PI3K), a member of the lipid kinase family, is an important regulator of signaling and intracellular vesicular trafficking.19 Several studies have found that the PI3K/AKT pathway is aberrantly activated in cancer20–22 and controls core cellular functions, such as proliferation and survival.23,24 The PI3K/AKT pathway plays a pivotal role in the progression of cancer.