The PI3K/AKT signaling pathway plays key roles in many biological and cellular functions, such as cell proliferation, growth, invasion, migration, and angiogenesis.85,168 It also plays a pivotal role in the progression of cancer.27,169,170 Recently, a great deal of research regarding the interaction of circRNA and PI3K/AKT signaling pathways has attracted significant research interest. The gene discussed is AKT1; the disease is cancer.