High expression of cirCHIPK3 significantly promotes cell migration, invasion, viability, and proliferation by targeting the miR-193a/HMGB1/PI3K/AKT axis.264 High circ0000442 expression induces suppression of cell viability and cell cycle arrest at the G1 phase and decreases colony formation in breast cancer.265 circ0000442 knockdown experiments have further confirmed this result. Here, AKT1 is linked to breast carcinoma.