AKT1 and neoplasm: PI3K/AKT pathway-related circRNAs (circPIP5K1A, circ0010882, circ0023409, ciRS-7, circMAN2B2, and circPVT1) are all obviously upregulated in gastric cancer.175–180 The levels of circ0010882 and circ0023409 are positively associated with tumor size and histological grade in gastric cancer patients.176,177 In addition, higher expression of circ0010882 or ciRS-7 is associated with shorter overall survival.