AKT1 and cancer: Ovarian, endometrial, and cervical cancer are three major malignant tumors causing a severe threat to women’s health.229,230 The downregulation of circRHOBTB3 not only attenuates cell proliferation and metastasis but also inhibits glycolysis by suppressing the PI3K/AKT pathway in ovarian cancer.231 Circ0002577 expression is markedly increased in endometrial cancer.232 Circ0002577 expression is positively correlated with the histological grade of the tumor, LNM, and lymph vascular space invasion.