AKT1 and kidney cancer: Circ-0072309 sponges miR-100 to inhibit the PI3K/AKT and mTOR pathways in kidney cancer.218 CircC3P1 exerts diverse biological functions by inhibiting the PI3K/AKT and NF-κB pathways by regulating the miR-21/PTEN axis219 (Fig. 4a).