AKT1 and hepatocellular carcinoma: CircHMGCS1 markedly upregulates the IGF2/IGF1R/PI3K/AKT axis to regulate proliferation by sponging miR-503-5p.193 The expression of circEPHB4 was negatively associated with tumor weight, size, and metastatic foci in vivo.189 A higher level of circ0079929 predicted decreased tumor size and weight in nude mouse models.187 CircCDK13 is an important negative regulator in the development and progression of HCC.184