Knockdown of circ100876 reduces cell proliferation, migration, and invasion and facilitates NSCLC cell apoptosis by regulating the miR-636/RET axis and PI3K/AKT signaling.247 The circ0018818/miR-767-3p/NID1/PI3K/AKT axis also plays a key role in the progression of lung cancer (Fig. 5). This evidence concerns the gene AKT1 and lung cancer.