Functionally, circNOLC1, circITCH, and circMBOAT2 govern multiple cellular processes, such as cell proliferation, migration, and invasion, via the circRNA/PI3K/AKT axis in PCa.225–227 Circ0001085 induces EMT in PCa cells in vitro.228 Circ0001085 regulates PCa progression through the PI3K/AKT pathway by sponging miR-196b-5p and miR-451a (Fig. 4b). The gene discussed is AKT1; the disease is posterior cortical atrophy.