Silencing of circ0002577 expression significantly inhibits the growth and metastasis of tumors in nude mouse models of endometrial cancer.232 The expression of circCSPP1 is markedly upregulated in cervical cancer tissues.233 CircCSPP1 expression inhibits cervical cancer cell apoptosis and promotes cell proliferation and migration via the miR-361-5p/ITGB1/PI3K/AKT axis in cervical cancer (Fig. 4d). The gene discussed is AKT1; the disease is endometrial cancer.