Treating chondrosarcoma with PI3K, Akt, and mTOR inhibitors reversed NGF-promoted inhibition of miR-149-5p expression, which suggests that NGF may increase LOX expression and chondrosarcoma metastasis by inhibiting miR-149-5p synthesis via the PI3K, Akt, and mTOR signaling cascades. The gene discussed is AKT1; the disease is chondrosarcoma.