HACE1 and central nervous system cancer: In addition, La/SSB can also protect pre-miRNAs from degradation by other nucleases.33 The present study demonstrated that some miRNAs such as miR-129-5p and miR-15b targeting La/SSB were downregulated when La/SSB was knocked down or HACE1/ HACE1C876S was ectopically expressed in glioma cells.