Given that the xenografts formed by HOMER3-AS1 overexpressed HCC cells had more macrophages infiltration, we further explored the potential influences of HOMER3-AS1 on macrophages using in vitro co-culture system by culturing HOMER3-AS1 overexpressed or silenced SK-HEP-1 cells with PMA-treated THP-1 cells (Fig. 6a). The gene discussed is HOMER3; the disease is hepatocellular carcinoma.